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Cleanroom HVAC

ISO class commissioning, HEPA integrity testing, particle counts, and pressure cascades, with a measurement behind every one. Cleanroom HVAC for Las Vegas regulated spaces.

NCI Certified
Aprilaire Partner
28 Years Experience
Cleanroom HVAC commissioning by Constant Air Balancing in Las Vegas, Nevada
NCI Certified Aprilaire Partner
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In Spec Or Out
A cleanroom has no setting called
CLOSE ENOUGH
ISO classes, HEPA integrity, particle counts, each one a measurement.

A cleanroom is defined entirely by numbers that have to stay inside a band, continuously, and be re-validated on schedule. The particle count per cubic foot at the certification class. The air change rate that keeps it there. The room pressure relative to its neighbors. The integrity of every HEPA filter. The supply-air velocity at the working face under unidirectional flow. None of these is a setting you dial in once. Every one is a measurement that either passes or fails, and out of spec means a rejected product, a contaminated batch, or a citation. Cleanroom HVAC is the discipline of holding all of them in spec and documenting that you did.

Constant Air Balancing and Services commissions and maintains cleanroom HVAC across Las Vegas for USP 797 and 800 compounding pharmacies, medical and dental clean spaces, semiconductor and electronics work areas, light-industrial cleanrooms, and ASHRAE Standard 170 healthcare suites. Chris is NCI certified with 28 years of air-balancing experience, and that is the credential cleanroom work actually requires, because cleanroom commissioning is measurement work to its core. Most general HVAC contractors cannot pass the validation that cleanroom owners need; the room is balance-driven, and balance is what we do.

Our scope is the full cleanroom envelope. Initial commissioning to a target ISO class under ISO 14644-1. Periodic re-certification on the schedule the regulatory environment requires. HEPA filter integrity testing with a photometer and challenge aerosol. Particle counting at ISO Class 5 through 8 across the work zone. Room pressure-cascade balancing, where a positive-pressure clean space has to stay defended against the lower-pressure spaces around it, verified at every door. Supply-velocity mapping under unidirectional flow. Humidity and temperature mapping across the work area. And the documentation package quality assurance and regulators require to keep the certification current.

We work with facility engineers, QA managers, and the validation engineers contracted to regulated environments, and the deliverable is always the document: particle-count plots, pressure-cascade diagrams, HEPA leak-test traverses, supply-velocity maps, and the certified TAB report that sits in the validation binder. Cleanroom and laboratory HVAC are related disciplines, and both build on the same commercial air balancing foundation, but in a cleanroom the whole system is balance, end to end.

Our Process
How a cleanroom gets certified
PROCESS
Documented measurement against the standard.
01

Specification Review

We review the cleanroom design, the target ISO class, the ASHRAE 170 or USP 797 and 800 references, the room pressure requirements, the supply-velocity target at the working face, and the humidity and temperature tolerances. Every measurement traces back to a written spec.

02

HEPA Integrity Testing

Every terminal HEPA filter is leak-tested with a calibrated photometer and challenge aerosol per the IEST RP-CC006 protocol. Each filter receives a certificate, and any failure is documented and the filter replaced before commissioning continues.

03

Particle Count Mapping

Particle counts are taken at the ISO 14644-1 specified locations across the work zone, at the occupancy state the certification requires. The room is certified to its ISO class only when every reading comes in below threshold.

04

Pressure Cascade and Velocity

Room-to-room differentials are measured with calibrated manometers so the clean space stays positive to its neighbors at every door. Supply face velocity is mapped on a grid across each terminal, and any imbalance is corrected at the damper, the fan speed, or the filter, then re-verified.

05

Documentation Package

Every measurement, certificate, adjustment, and reference standard goes into a validation-binder-quality document the QA team can present to a regulator or quality auditor. The certificate is the product as much as the airflow is.

Why Constant
Why a balancer certifies cleaner
CLEAN
Air balance is the credential that matters.

Air Balance DNA

Cleanroom HVAC is balance work first, equipment work second. Our 28 years of commercial air balancing is the credential that translates directly into cleanroom commissioning.

Calibrated Instrumentation

Particle counters, photometer and challenge aerosol for HEPA leak testing, certified manometers, and calibrated anemometers, every instrument carrying current calibration documentation.

Validation-Ready Documents

Reports formatted to fit directly into a QA validation binder, so regulators, auditors, and quality managers get the documentation they need without rework.

Tight Tolerances
The difference between conditioned and
CONTROLLED

A cleanroom does not forgive sloppy airflow. Particle counts, pressure cascades between rooms, and air change rates all have to hold to spec or the space fails certification. This is exactly where measurement-first work earns its keep, because every one of those targets is a number we can read and adjust.

We balance supply and return so the room holds positive or negative pressure relative to its neighbors, verify air changes per hour against the design, and document filter face velocities. Nothing here is projected, it is all measured at the grille and the filter. When the validation team shows up, the readings are already where they need to be.

Chris has run this kind of precision work across commercial and industrial sites for nearly three decades. See cleanroom and critical environment projects in the gallery.

Cleanroom HVAC airflow verification in Las Vegas, Nevada
Proof
What our partners
TRUST

Our cleanroom kept failing pressure validation and nobody could figure out why. Constant Air balanced the cascade between rooms, documented every reading, and we passed on the next inspection. They understood the spec better than the original installer did.

Facilities Director, Las Vegas

Questions
What Las Vegas cleanroom owners ask about
ANSWERS
Common questions about cleanroom HVAC in Las Vegas.
Do you commission USP 797 and USP 800 compounding pharmacies?
Yes. We commission ISO Class 5 primary engineering controls, ISO Class 7 buffer rooms and ante-rooms, and the surrounding pressure-cascade infrastructure. The documentation is formatted for state board of pharmacy and accreditation review.
Can you re-certify a cleanroom that is failing particle counts?
Yes. We diagnose the root cause first, a failing HEPA, a room pressure inversion, a supply-velocity drop, or contaminated process equipment, and target the fix to the actual failure. Replacing a HEPA on a leaking-pressure problem only resets the timer; we find and repair the upstream cause.
How does HEPA integrity testing work?
We introduce a challenge aerosol upstream of each terminal HEPA filter and scan the downstream face and frame with a calibrated photometer per IEST RP-CC006. Any reading above the leak threshold means a pinhole or a bad seal, which gets documented and corrected before the room is certified.
How often does an ISO Class 5, 7, or 8 cleanroom need re-certification?
Annually at minimum, every six months for higher-regulation environments such as USP 800 hazardous compounding and some semiconductor applications, and immediately after any HEPA change, fan-speed adjustment, or building-envelope modification.
Do you work with our third-party validation contractor?
Yes. We coordinate with the validation engineer, the QA team, and the original mechanical contractor on every regulated commissioning. The TAB report we deliver dovetails with their IQ, OQ, and PQ documentation rather than competing with it.

Still have questions? Contact us directly or call (702) 840-5163, we are happy to help.

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CLEANROOM
Schedule a commissioning or re-certification. Calibrated instruments, validation-ready documentation, a regulator-defensible report.

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Contact Constant Air Balancing & Services today for a free, no-obligation quote. We look forward to working with you.