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Lab & Cleanroom HVAC

Specialty environmental control for laboratories, medical clean spaces, and pharmaceutical environments — pressure cascades, particle counts, humidity, and temperature.

NCI Certified
Aprilaire Partner
28 Years Experience
Cleanroom and laboratory HVAC commissioning by Constant Air Balancing in Las Vegas
NCI Certified Aprilaire Partner
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Specialty Environments
Where measurement is the product
CLEANROOMS
ISO classes, USP chapters, ASHRAE 170 — and a measurement to back every one.

Cleanroom and laboratory HVAC is the highest measurement-density discipline in the trade. The air change rate, the room pressure relative to its neighbors, the HEPA filter integrity, the particle count per cubic foot at every certification class, the humidity band, the temperature band, and the supply-air velocity at the working face all have to be inside the spec — continuously, documented, and re-validated on the manufacturer’s schedule. There is no “close enough” in a cleanroom; there is in-spec or out-of-spec, and out-of-spec means the product gets rejected, the experiment gets contaminated, or the regulator writes you up.

Constant Air Balancing and Services brings 28 years of air-balance discipline to specialty cleanroom and laboratory environments across Las Vegas. We commission and maintain HVAC systems for medical and dental clean rooms, USP 797/800 compounding pharmacies, R&D laboratories, light-industrial cleanrooms, semiconductor and electronics work spaces, and ASHRAE Standard 170 compliant healthcare suites. Our air-balancing background uniquely qualifies us — measurement is the entire game in cleanroom commissioning, and most general HVAC contractors cannot pass the validation hurdle that cleanroom owners require.

Our scope covers initial commissioning, periodic re-certification, single-pass and recirculating system service, HEPA filter integrity testing, particle counting at ISO Class 5 through 8 work spaces, room pressure-cascade balancing (where positive-pressure clean spaces have to be defended against negative-pressure adjacent spaces, with measurement at every door), humidity and temperature mapping across the work area, and the documentation packages quality assurance and regulatory bodies require for ongoing certification.

We work with facility engineers, QA managers, lab directors, and the validation engineers contracted to the regulated environment. The deliverable is always documentation — particle count plots, pressure cascade diagrams, HEPA leak-test traverses, supply-velocity maps, and the certified TAB report that sits in the validation binder. Commercial air balancing is one input; in cleanroom work, the whole system is balance-driven.

Our Process
How we deliver results, not guesses
PROCESS
Documented methodology for every job.
01

Specification Review

We review the cleanroom design specs — ISO class target, ASHRAE 170 or USP 797/800 references, room pressure requirements, supply velocity targets at the working face, humidity and temperature tolerances. Every commissioning measurement traces back to a written spec.

02

HEPA Integrity Testing

Every terminal HEPA filter is leak-tested with a calibrated photometer and challenge aerosol per IEST RP-CC006 protocol. Each filter gets a certificate; failures are documented and replaced before commissioning continues.

03

Particle Count Mapping

Particle counts are measured at ISO 14644-1 specified locations across the work zone, at occupancy-state specifications. The room is certified to its ISO class only when every measurement comes in below threshold.

04

Pressure Cascade and Velocity

Room-to-room pressure differentials are measured with calibrated manometers. Supply face velocity is mapped on a grid across each terminal. Imbalances are corrected via damper adjustment, fan-speed change, or filter change as needed.

05

Documentation Package

Every measurement, every certificate, every adjustment, every reference standard cited. The deliverable is a validation-binder-quality document the QA team can present to a regulator or quality auditor.

Why Constant
What sets us apart for
LABS
Air balance is the credential that matters.

Air Balance DNA

Cleanroom HVAC is balance work first, equipment work second. Our 28 years of commercial air balancing is the credential that translates directly into cleanroom commissioning.

Calibrated Instrumentation

Particle counters, photometer + challenge aerosol for HEPA leak testing, certified manometers, calibrated anemometers — every instrument with current cal-cert documentation.

Validation-Ready Documents

Reports formatted to fit directly into a QA validation binder. Regulators, auditors, and lab directors get the documentation they need without rework.

Questions
What Las Vegas property owners ask about
ANSWERS
Common questions about lab and cleanroom hvac in Las Vegas.
Do you commission USP 797 and USP 800 compounding pharmacies?
Yes. We commission ISO Class 5 primary engineering controls (PECs), ISO Class 7 buffer rooms and ante-rooms, and the surrounding pressure-cascade infrastructure. Documentation is formatted for state board of pharmacy and accreditation review.
Can you re-certify an existing cleanroom that is failing particle counts?
Yes. We diagnose root cause first — failing HEPA, room pressure inversion, supply-velocity drop, or contaminated process equipment — and target the fix to the actual failure. Reactive HEPA replacement on a leaking-pressure problem just resets the timer; we identify and repair the upstream cause.
Do you work with the third-party validation contractor on regulated cleanrooms?
Yes. We coordinate with the validation engineer, the QA team, and the original mechanical contractor on every regulated commissioning. The TAB report we deliver dovetails with their IQ/OQ/PQ documentation rather than competing with it.
How often does an ISO Class 5/7/8 cleanroom need re-certification?
Annually at minimum, every six months for higher regulatory environments (USP 800 hazardous compounding, ISO 14644 for some semiconductor applications), and immediately after any HEPA filter change, fan-speed adjustment, or building-envelope modification.
Do you also provide laboratory exhaust and fume-hood balancing?
Yes. Lab fume hoods, snorkel exhausts, biological safety cabinets, and isolators all require face-velocity testing and exhaust-flow verification. We commission and maintain the full lab-air infrastructure, not just the cleanroom envelope.

Still have questions? Contact us directly or call (702) 840-5163 — we are happy to help.

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Ready for a cleanroom in spec
CLEANROOM
Schedule a commissioning or re-certification. Calibrated instruments, validation-ready documentation, regulator-defensible report.

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Contact Constant Air Balancing & Services today for a free, no-obligation estimate. We look forward to working with you.